Nicholas Wheeler, Oregon State University; David Harry, Oregon State University; Heather L. Merk, The Ohio State University
Most traits in forest trees are quantitatively inherited; that is, they are controlled by many genes, each of which controls a modest amount of the variance in that trait. A gene that controls some portion of the genetic variance of a phenotypic trait is called a quantitative trait locus, or QTL. It is possible to identify QTL and their relative location in the genome by placing them on genetic maps. This is done by demonstrating a statistically significant association between the quantitative trait phenotype and one or more genetic markers already located on a map. QTL mapping is a powerful tool for elucidating the genetic architecture of complex traits and provides a clearly defined approach for marker-assisted selection in applied breeding or natural environment settings. We will identify the key elements of QTL mapping and give some examples of how it has been done in forest trees. Additionally, we will reflect on some of the limitations of the QTL approach using pedigree crosses.
Module 9 — Mapping Quantitative Trait Loci (QTL)
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You can also watch the video on YouTube.
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Cite This Learning Module
- Wheeler, N., and D. Harry. Mapping quantitative trait loci (QTL) [Online Learning Module]. Genomics in Tree Breeding and Forest Ecosystem Management, Conifer Translational Genomics Network. eXtension Foundation. Available at: https://plant-breeding-genomics.extension.org/mapping-quantitative-trait-loci-qtl:-conifer-genomics-module-9/ (verified April 22, 2013).
- Nicholas Wheeler and David Harry developed the learning module content.
- Heather Merk developed the webpage.
Support for the Conifer Translational Genomics Network project and the development of the teaching modules hosted here was provided by the USDA/NRI CSREES Coordinated Agricultural Project (CAP) Award # 2007-55300-18603, the USDA/NIFA AFRI Applied Plant Genomics CAP Award #2009-85606-05680 and the USDA Forest Service. Development of this page was supported in part by the National Institute of Food and Agriculture (NIFA) Solanaceae Coordinated Agricultural Project, agreement 2009-85606-05673, administered by Michigan State University. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the United States Department of Agriculture.
Mapping_QTL.pdf (2.21 MB)