Creating a Kinship Matrix Using Microsatellite Analyzer

Tutorial Objectives

• Introduce the concept of a kinship matrix
• Visualize where a kinship matrix is used in the unified mixed model for association mapping
• Demonstrate how to generate a kinship matrix using Microsatellite Analyzer (MSA)

References Cited

• Cavalli-Sforza, L. L., and W. F. Bodmer. 1971. The genetics of human populations, W.H. Freeman and Company, NY.
• Lange, K. 2002. Mathematical and statistical methods for genetic analysis, 2nd edition. Springer-Verlag, NY.
• Yu, J. G. Pressoir, W. H. Briggs, I. V. Bi, M. Yamasaki, J. F. Doebley, M. D. McMullen, B. S. Gaut, D. M. Nielsen, J. B. Holland, S. Kresovich, and E. S. Buckler. 2006. A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nature Genetics 38: 203-208. (Available online at: http://dx.doi.org/10.1038/ng1702) (verified 10 Feb 2012).
• Zhu, C. M. Gore, E. S. Buckler, and J. Yu. 2008. Status and prospects of association mapping in plants. The Plant Genome 1: 5-20. (Available online at: http://dx.doi.org/10.3835/plantgenome2008.02.0089) (verified 10 Feb 2012).

External Link

• Dieringer, D. Microsatellite analyzer (MSA) [Online]. Available at: http://i122server.vu-wien.ac.at/MSA/MSA_download.html (verified 10 Feb 2012).

Funding Statement

Development of this page was supported in part by the National Institute of Food and Agriculture (NIFA) Solanaceae Coordinated Agricultural Project, agreement 2009-85606-05673, administered by Michigan State University. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the United States Department of Agriculture.

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